Statins
are cholesterol lowering drugs which millions of people take daily.
A
recent study, funded by the pharmaceutical makers of the cholersterol-lowering
drug Crestor, has exploded on the media scene, ostensibly showing benefits for
healthy people with "good" cholesterol levels if they take statins.
If
you haven't shut off televised "news" for good, now is a very good time.
After
all, this stunt is nothing more than another drug commercial, thinly veiled as
a breakthrough.
Americans are being
bombarded today by news reports of a breakthrough in the prevention of cardiovascular
disease (heart attacks, strokes and high blood pressure). The hype is undeserved,
the data less than compelling, and when it came to whether the statin drug used
in the study (Crestor) actually saved lives, the headlines should have said the
drug trial failed and that it raised the risk for diabetes. (Sardi)
Now
check out the headlines...
CNN:
Healthy men and
women with good cholesterol levels could significantly reduce their risk of heart
disease by taking cholesterol-lowering drugs, better known as statins, according
to a study released Sunday. (cnn.com)
Guess
who funded the study?
The
makers of Crestor, which was used in the study.
Sardi:
The drug companies
now assert that normally healthy people should now take statin drugs, even if
they have low-to-normal cholesterol levels, because Crestor reduced C-reactive
protein, a marker of inflammation. This claim would expand the use of statin drugs
to millions more Americans and reel in billions of dollars of sales for the maker
of Crestor. [...] Major efforts will likely be made to promote Crestor on TV,
prodding healthy people with normal cholesterol levels to begin taking a drug
known to cause liver toxicity and muscle problems, a drug that costs $3.45 per
day ($1259 a year). (Sardi)
In
contrast, one could take simple vitamin C and E as a precautionary measure, which
is not toxic to the liver as is Crestor, according to Sardi.
Sardi
adds:
The
4-year study of 18,000 patients was stopped suddenly prior to the 2-year mark
because it allegedly showed startling improvements in cardiovascular health. But
generally studies are halted when greater risk is identified. Halting the study
prematurely may have hidden the occurrence of the characteristic side effects
caused by the drug (liver toxicity and muscle problems). The drug also increased
the risk for diabetes, which represents disease substitution, not disease prevention.
(Sardi)
Reminds
me of similar
big studies funded by pharmaceutical industries with conclusions based on
fuzzy math and statistical trickery.
I
wonder how many people will trust this new "study," in the wake of Vioxx?
11/17/08
Update
Well,
well, look what we have here.
Turns
out another
study has been published supposedly debunking vitamins C and E and their preventative
benefits when it comes to cancers and heart disease.
Very
nice timing. How convenient that this comes out right after the above study, encouraging
healthy people to take dangerous
statins.
The
Washington Post:
SUNDAY,
Nov. 16 (HealthDay News) -- Coming on the heels of two studies discounting the
usefulness of vitamin B, folic acid, vitamin D and calcium supplements for cancer
prevention, U.S. researchers report that vitamins C and E supplements won't help
prevent cancer, either.
The
same team also recently reported that vitamin C and E supplements weren't helpful
in protecting users against heart disease.
"At
least in the context of two very common outcomes -- cardioprotection and chemoprevention
-- we see no compelling evidence to take vitamin E or C supplements," said
one of the study's authors, Dr. Howard Sesso, an assistant professor of medicine
in the division of preventive medicine at Brigham and Women's Hospital in Boston.
In
fairness, the article acknowledged the importance of nutrition:
"This is preliminary
data, but it is pretty consistent with what we're seeing in other research with
individual nutrients. When you take the nutrient out of its natural environment,
it may not be protective," said Jennifer Crum, a nutritionist at the New
York University Cancer Institute, who added that in foods, vitamins and other
nutrients likely work together to provide protection against cancer.
"People
are starting to realize the importance of the overall picture," said Crum,
who recommended that people begin by making small changes, such as exercising
a little bit longer or adding another vegetable a day to your diet. "When
people make small changes for their health -- exercising for 20 to 30 minutes
a day, eating better -- we see lower rates of cancer recurrence," she said.
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